Henry R.L. et.al., Comparison of preservative-free and preservative-containing ipratropium bromide. Journal of Paediatrics and Child Health Volume 25, 2 (1989).
Abstract from the original article:
A double-blind crossover study was performed on 33 children with asthma to compare the effectiveness of nebulized solutions of preservative-containing and preservative-free ipratropium bromide. Both solutions produced bronchodilation. No significant differences were found between the two solutions at any time after nebulization in minimum and maximum changes from baseline value or in the areas under the lung function time curves. The presently formulated preservative-containing ipratropium bromide solution was not shown to be inferior to a preservative-free compound..
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