Quats are well-known antiseptics and have a long history of use in a wide range of both human and veterinary products. They act on a wide range of microorganisms, from gram+ to gram- bacteria, moulds and yeasts.
Our FeF Quats are odourless and colourless, and their effectiveness in all pH ranges combined with their ability to mix well in most formulations, make them an ideal antimicrobial ingredient.
No matter the application, for formulations coming into contact with either healthy or damaged buccal tissue, it is necessary to utilize only the purest and safest ingredients.
Lozenges: FeF Benzalkonium Chloride (BKC) is used as an API in lozenges to treat superficial infections in the mouth and throat. Our crystalline product FeF CTAB is found as an API in lozenges to treat throat infections at typically 1.0 mg/lozenge.
Gels and creams: FeF Benzalkonium Chloride (BKC) is also often found in gels and creams at typical concentrations of 0,01 to 0,1%, to treat herpes and cold sores infections, or as an excipient in pain-relieving gum gels.
Antiseptic mouth sprays with FeF Benzalkonium Chloride (BKC) are also common. Dentistry products: FeF Quats are also used either as an active antiseptic or a preservative in for example rinsing fluids and antiseptic fills.
Solubility: Quats are miscible with water or lower alcohols, such as methanol, ethanol and propanol in all ratios. Quats are not miscible with benzene or ether. Indicative solubility of Quats in %w/w at 20°C in water:
Solubility decreases as the alkyl chain length increases.
Compatibility: Quats can be combined with e.g. alcohol and chlorhexidine and with the most commonly used compounds in oral & dental formulations. Mixing Quats with ordinary soaps and/or with anionic detergents may decrease the activity. As Quats are cationic compounds, they should not be mixed with anionic compounds as this would have a neutralizing effect. Quats can be inhibited by Tween™ and by lecithin. Avoid mixing Benzalkonium Chloride (BKC) with citrates, iodides, nitrates, perman ganates, salicylates, silver salts and tartrates. Incompatibilities have also been reported with other substances including aluminium, fluorescin sodium, hydrogen peroxide, kaolin and some sulfonamides.
Stability: 5 years shelf life.
Other: Colourless and odourless in finished product formulation, Easy to formulate, Surface active / adhesive, Non-volatile and very stable.
As opposed to bacteriostatic/fungistatic compounds which only prevent micro-organisms from dividing (growing), Quats are bactericidal/fungicidal, meaning they will kill micro-organisms, whether they are in a growth phase or not.
FeF Quats have been tested against several relevant microbial strains, and shown to be effective against a wide range of micro-organisms at low concentrations. FeF Quats are compared here with ethanol and with a positive control containing Meropenem (a broad-spectrum antibiotic).
Table 1: Minimal Inhibitory Concentrations. Mean results in % or μg/ml.