Vaccine production

Description

CTAB (Cetrimonium Bromide) is a powerful cationic surfactant, that can be used in vaccine downstream processing in both bacterial and viral vaccines.

 

Bacterial, polysaccharide-based vaccines:

  • Polysaccharide vaccines are a unique type of inactivated subunit vaccine composed of long chains of sugar molecules, that make up the surface capsule of certain bacteria. These vaccines target e.g. pneumococcal and meningococcal diseases.
  • Polysaccharide vaccines are commonly found in standard children vaccination programs.
  • CTAB (Cetrimonium Bromide) is recommended by the WHO in bacterial vaccine manufacturing as a purification agent for polysaccharide vaccines.
  • CTAB serves as a surfactant in a buffer system, to remove membrane lipids and promote cell lysis, to “free-up” the polysaccharides.

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Viral vaccines:

  • CTAB can be used in downstream processing of viral vaccines, for example influenza vaccines.
  • CTAB is used as a cationic detergent to isolate the antigenic agents, e.g. influenza HA proteins.
  • It can be used in egg-based, cell-based and recombinant (DNA) vaccines for downstream purification.
  • Sub unit isolation can be done using a mixture of Tween 80 with CTAB, to separate RNP (Ribonucleoprotein) particles from the surface antigen proteins by centrifugation.

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Novo Nordisk Pharmatech is the only quaternary ammonium compound (Quat) manufacturer offering CTAB in cGMP manufactured pharmaceutical grade, in full compliance with ICH Q7.

This means:

  • Full traceability
  • High product purity
  • Full USP/NF compliance
  • Audit access
  • Full regulatory documentation package
  • Manufactured under fully validated processes

If you are making a cell-based vaccine, you can consider using our recombinant Insulin to promote cell growth and viability.

View our Quats Brochure

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Vaccine production

Contact

Mette Borgaard
Customer Service Assistant

Phone: +45 2429 4134
Email: [email protected]