Did you know that Benzalkonium Chloride is a good option?

Replacing Triclosan with BKC

Triclosan (5-chloro-2-(2,4-dichlorophenoxy) phenol) is either banned or under scrutiny due to its possible effect in the disruption of hormonal development and the environment.

At equivalent antimicrobial efficacy, Benzalkonium Chloride (BKC/BAC/BAK/BZK) is a safer alternative with superior properties, including better water solubility and wider pH range of activity.

The regulatory situation:

ECHA has placed Triclosan under assessment as PBT (Persistent, Bio- accumulative and Toxic) and ED (Endocrine disrupting)​. Triclosan is banned by the US FDA in 2016 from OTC healthcare antiseptic products without premarket review.

For these reasons, you may be looking for safer alternatives.

For healthcare uses like surgical scrubs and handwashes, topical antiseptics, coating in medical devices, etc. Triclosan can be replaced by Benzalkonium Chloride (BKC/BAK/BZK).

Benzalkonium Chloride can replace Triclosan 1:1

Benzalkonium Chloride (BKC) is as effective as Triclosan in killing a wide range of microorganisms, with few variations in​ MIC concentrations.

The table below shows results from a test performed by the Danish Serum Institute, where colonies were suspended to a turbidity of 0.5 McFarland or 0.13 on a colorimeter, and further diluted in a broth to 1×106 CFU/ml and incubated overnight at 370C.​ The antimicrobial concentration range was 0.00001 to 0.01%.

Replacing Triclosan with BKC

RESEARCH REPORT No 182-01-04  ”Minimal Inhibitory Concentration (MIC) of Quats Benzalkonium Chloride (BKC), Cetrimonium Bromide (CTAB), Cetrimide (Tetradonium Bromide) and Triclosan against selected bacteria strains.” Statens Serum Institut, 2017.

Supported by these results, an existing product can be re-formulated with BKC using an equal concentration as Triclosan.

As a supporting tool, here is information on BKC compatibility and incompatibility:

Replacing Triclosan with BKC

Wondering how BKC and Triclosan compare to other antimicrobials? The table below summarizes the characteristics of several antimicrobial ingredients found on the market.

Comparison of antimicrobials

Replacing Triclosan with BKC

Extract from our white paper “Oral formulations – Selecting the right antiseptic for your formulation”

Compared to Triclosan, BKC is more soluble in water and is not affected by temperature as Triclosan can be. BKC’s pH range of activity is also wider, and it offers surfactant residual activity.

Why choose Benzalkonium Chloride?

  • Proven bactericide against a broad spectrum of microorganisms:
    Gram + and – & acid-fast bacteria, yeast, moulds, enveloped viruses
  • Effective through a wide pH range (4-10/11)
  • Very stable at various temperatures and pH
  • Non-volatile
  • Cost effective due to activity at low concentration
  • Strong surfactant can support active ingredient delivery and offers residual activity
  • Safe to use, non-flammable and widely available
  • Does not add colour or odour to finished formulations
  • Soluble in water (Triclosan is poorly soluble in water)
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Chantale Julien
Chantale Julien
Product Manager

Phone: +45 4029 7906
Email: chju@novonordisk.com