Insulin price

Recombinant Insulin and its Role in Cell Culture Media Systems for Upstream Manufacturing:

Recombinant insulin is a key component of cell culture media systems, with proven ability to optimise upstream manufacturing. As it binds to a receptor, insulin activates the intracellular signalling pathways involved in regulating cell growth, cell differentiation, cell survival, and cellular glucose uptake. When used as a supplement in commercially available, serum-free cell culture media, insulin helps to promote cell growth and enhance protein yields.

Novo Nordisk Pharmatech is the leading supplier of recombinant insulin for cell culture and bioprocessing applications. Recombinant insulin is sourced directly from our parent company, Novo Nordisk, the world’s largest producer of therapeutic insulin.

To learn more about the applications, pricing, and delivery of Insulin Human AF, read more here. 


Applications of Recombinant Insulin in Cell Culture Media Systems:

Insulin is used to optimise cell culture media systems for a range of cell lines, including CHO-S, CHO-K, HEK-293, and Sf9. As a result, it is used to improve the upstream manufacturing of monoclonal antibodies, virus vaccines, and viral vectors.

When applied to a fed-batch culture of CHO-K1 cells for monoclonal antibody (mAb) production, insulin can be used to increase yields through the basal medium and through the feeding medium. In a two-part experiment, researchers found that 2 mg/L insulin in the basal medium increased cell growth by 17% and antibody production by 51%. Meanwhile, supplementing the feeding medium with 2 mg/L insulin improved antibody production by 49%.

Data also supports the use of recombinant insulin in gene therapy manufacturing, where it can help manufacturers scale up viral vector production. Supplementing HEK293 cells with Insulin Human AF resulted in a 68% increase in titres of AAV2, AAV5, and AAV8. In addition, when tested in a HEK-293 cell line for lentivirus production, a 120% titre increase followed.

Recombinant insulin can also help the viral vaccine industry meet high demand. In HEK-293 cells, Insulin Human AF supplementation produced a four-fold increase in cell growth and a 60% increase in virus production.


Enabling Better Medicines, Enable Better Lives with Recombinant Insulin: Price and Quality Assurance

Recombinant insulin from Novo Nordisk Pharmatech is designed for use in serum-free (chemically defined) media and does not contain or use in its manufacturing any raw materials derived from animal origin. Recombinant Insulin is manufactured in Novo Nordisk’s cGMP facilities in accordance with an ISO 9001 quality system. The high purity and batch-to-batch consistency of our insulin helps manufacturers control their bioprocessing and achieve strong results time after time.

Insulin Human AF comes in a dry, crystalline form to be dissolved in water for further manufacturing only. The product is available in 1g, 10g, 50g, 100g, and 1kg packaging sizes.


Insulin Price Information:

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