Unlocking the potential of antimicrobial preservation and HPLC method validation for Benzalkonium Chloride
Are you seeking the perfect equilibrium between antimicrobial preservation and patient safety? Do you require expert assistance in validating your HPLC method for recovering Benzalkonium Chloride in a finished formulation? Look no further.
In our groundbreaking technical paper, we delve into a comprehensive exploration of Benzalkonium Chloride concentrations, aiming to pinpoint the optimal balance between efficacy and safety using standard AET (Antimicrobial Efficacy Testing). Our rigorous approach involves HPLC method validation and filtering optimization, delivering invaluable, hands-on insights tailored to optimize your formulation and testing protocols.
HPLC-based methods in BKC formulations
Benzalkonium Chloride (BKC) is a powerful preservative used to prevent microbial contamination in ophthalmic solutions, nasal sprays, oral, and topical preparations. While effective at low concentrations, reducing BKC is important to minimize irritation risks.
This study identified the lowest effective concentration of BKC through Antimicrobial Effectiveness Testing (AET) and developed an HPLC-based method to verify the concentration of tested solutions. Filter compatibility tests were also performed to ensure consistent BKC potency. These findings offer key insights for analytical and formulation scientists aiming to optimize BKC use while balancing product efficacy and patient safety.
Download the application note
Join us to refine your research and laboratory proficiency with the actionable knowledge provided in our technical paper. Download our application note by filling the form below.
