Regulation of the cell cycle by insulin and IGF1
Pierre De Meyts
MD, PHD, F.A.C.E.
An increase in the number of cells growing in cell culture is the result of two opposing effects: an increase in the number of cells that traverse the cell cycle and divide into two daughter cells (mitosis), or a decrease in the number of cells that die, principally through programmed cell death (apoptosis), or both.
Insulin and IGF-I are both capable of facilitating cell progression through the cell cycle, and of inhibiting apoptotic mechanisms.
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