Oral or dental formulations

Oral or dental formulations

Quats are well-known antiseptics and have a long history of use in a wide range of both human and veterinary products. They act on a wide range of microorganisms, from gram+ to gram- bacteria, moulds and yeasts.

Our FeF Quats are odourless and colourless, and their effectiveness in all pH ranges combined with their ability to mix well in most formulations, make them an ideal antimicrobial ingredient.

Applications

No matter the application, for formulations coming into contact with either healthy or damaged buccal tissue, it is necessary to utilize only the purest and safest ingredients.

FeF Quats can be used either as excipients or active pharmaceutical ingredients (APIs) for oral and dental formulations.

Lozenges: FeF Benzalkonium Chloride (BKC) is used as an API in lozenges to treat superficial infections in the mouth and throat.

Gels and creams: FeF Benzalkonium Chloride (BKC) is also often found in gels and creams at typical concentrations of 0,01 to 0,1%, to treat herpes and cold sores infections, or as an excipient in pain-relieving gum gels.

Antiseptic mouth sprays with FeF Benzalkonium Chloride (BKC) are also common. Dentistry products: FeF Quats are also used either as an active antiseptic or a preservative in for example rinsing fluids and antiseptic fills.

Antimicrobial effect

FeF Quats are effective at all pH levels. However their effectiveness increases when the pH increases. The higher the pH, the lower the concentration needed to obtain an antimicrobial effect.

As opposed to bacteriostatic/fungistatic compounds which only prevent micro-organisms from dividing (growing), Quats are bactericidal/fungicidal, meaning they will kill micro-organisms, whether they are in a growth phase or not.
FeF Quats have been tested against several relevant microbial strains, and shown to be effective against a wide range of micro-organisms at low concentrations. FeF Quats are compared here with ethanol and with a positive control containing Meropenem (a broad-spectrum antibiotic).

Table 1: Minimal Inhibitory Concentrations. Mean results in % or μg/ml.